Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity
This dataset consists of data from in vitro developmental neurotoxicity new approach methodologies (DNT-NAMs). Assays include evaluations of proliferation, apoptosis, viability, neurite outgrowth, synaptogenesis and network formation. A variety of cell models are utilized depending on the assay, and each assay may have multiple endpoints. Data have been collected and evaluated using the ToxCast PipeLine (tcpl).
This dataset is associated with the following publication:
Carstens, K., A. Carpenter, M. Martin, J. Harrill, T. Shafer, and K. Friedman. Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1): 62-79, (2022).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Katie Friedman",
"hasEmail": "mailto:paul-friedman.katie@epa.gov"
}
|
| description | This dataset consists of data from in vitro developmental neurotoxicity new approach methodologies (DNT-NAMs). Assays include evaluations of proliferation, apoptosis, viability, neurite outgrowth, synaptogenesis and network formation. A variety of cell models are utilized depending on the assay, and each assay may have multiple endpoints. Data have been collected and evaluated using the ToxCast PipeLine (tcpl). This dataset is associated with the following publication: Carstens, K., A. Carpenter, M. Martin, J. Harrill, T. Shafer, and K. Friedman. Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1): 62-79, (2022). |
| distribution |
[
{
"title": "https://clowder.edap-cluster.com/datasets/61147fefe4b0856fdc65639b?space=6112f2bee4b01a90a3fa7689#folderId=61b1235de4b0d5d4d1e33049&page=0",
"accessURL": "https://clowder.edap-cluster.com/datasets/61147fefe4b0856fdc65639b?space=6112f2bee4b01a90a3fa7689#folderId=61b1235de4b0d5d4d1e33049&page=0"
},
{
"title": "https://github.com/USEPA/CompTox-Evaluation-DNTNAMs",
"accessURL": "https://github.com/USEPA/CompTox-Evaluation-DNTNAMs"
}
]
|
| identifier | https://doi.org/10.23719/1526375 |
| keyword |
[
"New Approach Methods (Alternatives to Animal Testi",
"ToxCast",
"computational toxicology",
"developmental neurotoxicity",
"high-throughput"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2021-12-09 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfac018"
]
|
| rights |
null
|
| title | Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity |
