Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening
Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health Perspectives, Vol 133, Issue 6, 067013, June 2025. DOI: https://doi.org/10.1289/EHP16024, PMC12165737
R scripts for reproducing all analyses are available on Github (https://github.com/USEPA/CompTox-HTTr-RCAS). All sequencing data are available via the Gene Expression Omnibus repository (accessionnumbers GSE274318 for U-2 OS and GSE284321 for HepaRG). High-throughput screening assay data are available from InvitroDB via download 29 or the USEPA CompTox Chemicals Dashboard(https://comptox.epa.gov/dashboard/).
This dataset is associated with the following publication:
Rogers, J., J. Bundy, J. Harrill, R. Judson, K. Friedman, and L. Everett. Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 133(6): 067013, (2025).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Logan Everett",
"hasEmail": "mailto:everett.logan@epa.gov"
}
|
| description | Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health Perspectives, Vol 133, Issue 6, 067013, June 2025. DOI: https://doi.org/10.1289/EHP16024, PMC12165737 R scripts for reproducing all analyses are available on Github (https://github.com/USEPA/CompTox-HTTr-RCAS). All sequencing data are available via the Gene Expression Omnibus repository (accessionnumbers GSE274318 for U-2 OS and GSE284321 for HepaRG). High-throughput screening assay data are available from InvitroDB via download 29 or the USEPA CompTox Chemicals Dashboard(https://comptox.epa.gov/dashboard/). This dataset is associated with the following publication: Rogers, J., J. Bundy, J. Harrill, R. Judson, K. Friedman, and L. Everett. Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 133(6): 067013, (2025). |
| distribution |
[
{
"title": "https://github.com/USEPA/CompTox-HTTr-RCAS",
"accessURL": "https://github.com/USEPA/CompTox-HTTr-RCAS"
},
{
"title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318",
"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318"
},
{
"title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321",
"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321"
}
]
|
| identifier | https://doi.org/10.23719/1532377 |
| keyword |
[
"Hazard Assessment",
"chemical prioritization",
"high-throughput transcriptomics",
"new approach methodologies"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-03-25 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1289/ehp16024",
"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165737"
]
|
| rights |
null
|
| title | Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening |
