Seasonal PM exposure and respiratory viral infection
This dataset provides information on how differences in chemical composition of PM across seasons contribute to different biological effects and modify antiviral host defense response in airway epithelium. The findings indicate that chemical differences in seasonal PM from the winter, spring, and fall coinciding with influenza season, likely contribute to the adjuvant pro-inflammatory effects of exposure on antiviral host response, suggesting that heightened inflammation early in infection could contribute to worsened pathogenesis.
This dataset is associated with the following publication:
Brocke, S., T. Smyth, H. Dang, A. Speen, Y.H. Kim, C. Christianson, K. Kovalcik, J. Pancras, M. Hays, Z. An, W. Wu, and i. jaspers. Seasonal PM2.5 exposures induce differential responses to influenza A virus infection in primary human airway epithelial cells. Particle and Fibre Toxicology. BioMed Central Ltd, London, UK, 22: 28, (2025).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Yong Ho Kim",
"hasEmail": "mailto:kim.yongho@epa.gov"
}
|
| description | This dataset provides information on how differences in chemical composition of PM across seasons contribute to different biological effects and modify antiviral host defense response in airway epithelium. The findings indicate that chemical differences in seasonal PM from the winter, spring, and fall coinciding with influenza season, likely contribute to the adjuvant pro-inflammatory effects of exposure on antiviral host response, suggesting that heightened inflammation early in infection could contribute to worsened pathogenesis. This dataset is associated with the following publication: Brocke, S., T. Smyth, H. Dang, A. Speen, Y.H. Kim, C. Christianson, K. Kovalcik, J. Pancras, M. Hays, Z. An, W. Wu, and i. jaspers. Seasonal PM2.5 exposures induce differential responses to influenza A virus infection in primary human airway epithelial cells. Particle and Fibre Toxicology. BioMed Central Ltd, London, UK, 22: 28, (2025). |
| distribution |
[
{
"title": "https://dataverse.unc.edu/dataset.xhtml?persistentId=doi%3A10.15139%2FS3%2FCL8CK9&version=DRAFT",
"accessURL": "https://dataverse.unc.edu/dataset.xhtml?persistentId=doi%3A10.15139%2FS3%2FCL8CK9&version=DRAFT"
}
]
|
| identifier | https://doi.org/10.23719/1532336 |
| keyword |
[
"Influenza",
"in vitro",
"inflammation",
"particulate matter (PM)"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html |
| modified | 2024-07-18 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1186/s12989-025-00643-8",
"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12570438"
]
|
| rights |
null
|
| title | Seasonal PM exposure and respiratory viral infection |
