Found 9 datasets matching "CFTR".
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Background Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport may be the mechanism...
Search relevance: 157.61 | Views last month: 0 -
Background This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR, in mouse aorta...
Search relevance: 150.73 | Views last month: 0 -
Cystic fibrosis is a genetic disease that is associated with abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into...
Search relevance: 145.59 | Views last month: 1 -
The increase in numbers of adults with cystic fibrosis (CF) has allowed us to identify previously unrecognized chronic complications of CF, as well as appreciate unique presentations of cystic...
Search relevance: 137.48 | Views last month: 0 -
The cystic fibrosis transmembrane conductance regulator (CFTR) has been known for the past 11 years to be a membrane glycoprotein with chloride channel activity. Only recently has the...
Search relevance: 100.32 | Views last month: 1 -
Background Endoplasmic reticulum retention of misfolded cystic fibrosis transmembrane conductance regulator (CFTR) mutants and their rapid degradation is the major cause of cystic...
Search relevance: 92.62 | Views last month: 0 -
These secondary data have been produced from the gene expression data generated from duodena of mice exposed to hexavalent chromium in drinking water and deposited in the GEO repository under...
Search relevance: 73.32 | Views last month: 2 -
Background SFHR (small fragment homologous replacement)-mediated targeting is a process that has been used to correct specific mutations in mammalian cells. This process involves both...
Search relevance: 58.49 | Views last month: 0 -
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by...
Search relevance: 34.06 | Views last month: 2
