Found 9 datasets matching "IC50".
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Background Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania infantum. The failures of current treatment with pentavalent antimonials are partially...
Search relevance: 39.16 | Views last month: 0 -
Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated...
Search relevance: 35.27 | Views last month: 0 -
The experimental data were taken from Simon et al., who compiled potency data for effects related to neurotoxicity from four experimental datasets, Stenberg et al. [18] and Wigestrand et al. The...
Search relevance: 35.08 | Views last month: 0 -
Background The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin...
Search relevance: 31.05 | Views last month: 0 -
Background Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human...
Search relevance: 28.30 | Views last month: 0 -
Background Acyclovir (ACV) resistant herpes simplex virus (HSV) isolates can be readily selected in animal infection models receiving suboptimal ACV treatment, however no comparative...
Search relevance: 26.17 | Views last month: 0 -
Background Maitotoxin (MTX) initiates cell death by sequentially activating 1) Ca2+ influx via non-selective cation channels, 2) uptake of vital dyes via formation of large pores, and 3)...
Search relevance: 25.81 | Views last month: 0 -
Background The signal transduction pathways mediated by retinoic acid play a critical role in the regulation of cell growth and differentiation during embryogenesis and hematopoiesis as...
Search relevance: 25.07 | Views last month: 0 -
Chemistry, fish species, atmospheric pollutants, and temperature profile were collected using CTD casts and other collection methods in the Southern California Bight from 28 April 1977 to 04 March...
Search relevance: 8.05 | Views last month: 0
