Found 19 datasets matching "IVIVE".
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We report on new, in vivo TK experiments in rats for 26 chemicals more commonly associated with non-therapeutic and/or unintentional exposure. These chemicals, and an additional 19 chemicals from...
Search relevance: 104.81 | Views last month: 0 -
This study represents the first report applying IVIVE approaches and exposure comparisons using the entirety of the Tox21 federal collaboration chemical screening data, incorporating assay...
Search relevance: 68.86 | Views last month: 1 -
This paper described development of an in vitro/in vivo model that accounts for first pass clearance effects. The model details are contained in the supporting information for the paper. This...
Search relevance: 67.04 | Views last month: 0 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 60.68 | Views last month: 2 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 58.63 | Views last month: 1 -
The supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics11120951/s1. Text S1: Chemicals; Text S2: Thyroid Hormone Chemicals and Analysis; Text S3: In Vivo...
Search relevance: 46.76 | Views last month: 2 -
The purpose of is this study was to evaluate the potential for biotransformation in the gastrointestinal tissues (GIT) of fish to impact chemical bioaccumulation. In vitro biotransformation of...
Search relevance: 44.51 | Views last month: 0 -
All relevant data are within the manuscript, its Supporting Information files, and the httk R software package v1.9.2. This dataset is associated with the following publication: Honda, G., R....
Search relevance: 37.25 | Views last month: 0 -
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses Using High-content Imaging in...
Search relevance: 35.48 | Views last month: 5 -
This dataset, presented as an Excel spreadsheet, contains all data presented as figures and tables in an article by Nichols et al, entitled "In vitro-in vivo extrapolation of hepatic...
Search relevance: 32.95 | Views last month: 1 -
This paper describes the results of an international ring trial (round robin study) of in vitro methods used to measure chemical biotransformation in fish. Researchers at six laboratories in the...
Search relevance: 32.18 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 32.09 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 30.86 | Views last month: 0 -
Data for Reardon AJF, et al., From vision toward best practices: Evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow. Front. Toxicol....
Search relevance: 29.66 | Views last month: 0 -
Data sets in the context of this project are the model files, model input parameter sets, and data generated at the US EPA/ORD/National Health and Environmental Effects Research Laboratory that...
Search relevance: 29.65 | Views last month: 0 -
The data used in this analysis was obtained from published literature and available through the high-throughput toxicokinetic (HTTK) R package. The dataset consists of 1486 chemicals that span a...
Search relevance: 28.99 | Views last month: 0 -
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC...
Search relevance: 28.68 | Views last month: 2 -
This dataset contains model code and supporting analysis files necessary to evaluate the impact of variability in human hepatic scaling factors. Variation in scaling factor values impacts...
Search relevance: 28.66 | Views last month: 0 -
this file has the metadata sheet and the data used for the figures and tables in the PFQ vs BPC manuscript. This dataset is associated with the following publication: Gray, E., J. Furr, J....
Search relevance: 28.01 | Views last month: 0
