Found 6 datasets matching "Intestinal metabolism".
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Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the...
Search relevance: 219.25 | Views last month: 1 -
Background Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have been...
Search relevance: 64.57 | Views last month: 0 -
Methods of controlling phosphate metabolism and metabolic acidosis in patients suffering from renal failure and associated hyperphosphatemia or patients predisposed to development of a...
Search relevance: 64.48 | Views last month: 1 -
The effect of dietary lead (Pb) on the murine intestinal microbiome was explored to determine if there was an association between microflora modulation and Pb source. Mice were treated with...
Search relevance: 59.70 | Views last month: 0 -
This paper described development of an in vitro/in vivo model that accounts for first pass clearance effects. The model details are contained in the supporting information for the paper. This...
Search relevance: 53.83 | Views last month: 0 -
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
Search relevance: 44.45 | Views last month: 1
