Found 28 datasets matching "MHC".
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Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction
Search relevance: 157.86 | Views last month: 1 -
T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse...
Search relevance: 149.22 | Views last month: 0 -
Background Major histocompatibility complex (MHC) molecules present peptides to T lymphocytes. It is of critical biological and medical importance to elucidate how different MHC alleles...
Search relevance: 142.12 | Views last month: 1 -
Background Quantitative information on the types of inter-atomic interactions at the MHC-peptide interface will provide insights to backbone/sidechain atom preference during binding....
Search relevance: 132.06 | Views last month: 0 -
Most techniques that identify antigen-specific T cells are dependent on the response of these cells to the relevant antigen in culture. Soluble multimers of MHC molecules, when occupied with the...
Search relevance: 131.55 | Views last month: 0 -
In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since...
Search relevance: 128.18 | Views last month: 0 -
Background Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class...
Search relevance: 120.82 | Views last month: 1 -
Background Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of...
Search relevance: 108.65 | Views last month: 0 -
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these...
Search relevance: 89.11 | Views last month: 0 -
The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The...
Search relevance: 65.57 | Views last month: 1 -
Genes in the human leukocyte antigen (HLA) region remain the most powerful disease risk genes in rheumatoid arthritis (RA). Several allelic variants of HLA-DRB1 genes have been associated with RA,...
Search relevance: 52.86 | Views last month: 0 -
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In...
Search relevance: 49.05 | Views last month: 0 -
There is provided a tolerogenic human peptide, capable of binding to an MHC class I or II molecule without further antigen processing, for use in the treatment and/or prevention of multiple...
Search relevance: 40.99 | Views last month: 0 -
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked...
Search relevance: 40.33 | Views last month: 0 -
Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively...
Search relevance: 39.07 | Views last month: 0 -
T-cell epitopes represent sampled environmental- and self-peptides loaded into major histocompatibility complex (MHC) proteins. Bioinformatic tools have been produced to predict these interactions...
Search relevance: 38.89 | Views last month: 0 -
Mesophotic hard corals (MHC) are increasingly threatened by a growing number of anthropogenic stressors, including impacts from fishing, land-based sources of pollution, and ocean acidification....
Search relevance: 38.19 | Views last month: 0 -
Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the pathobiology of...
Search relevance: 35.28 | Views last month: 3 -
Background Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow during cytokinesis....
Search relevance: 34.91 | Views last month: 0 -
This dataset provides the locations of all clinics in Austin/Travis County participating in the Vaccines for Children (TVFC) and Adult Safety Net (ASN) programs administered by Austin Public...
Search relevance: 32.73 | Views last month: 0
