Found 467 datasets matching "Read-across".
-
These new analysis builds on the baseline GenRA approach and presents a proof of concept of how other contexts of similarity namely physchem can be implemented into a search strategy for...
Search relevance: 220.86 | Views last month: 0 -
The emission data used is based on this publication. This dataset is associated with the following publication: Takkellapati, S., and M.A. Gonzalez. Application of read-across methods as a...
Search relevance: 201.69 | Views last month: 0 -
Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains an ongoing challenge with several efforts...
Search relevance: 180.61 | Views last month: 0 -
Dataset for journal article "Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in...
Search relevance: 167.68 | Views last month: 0 -
Read-across (RAX) is a widely used data gap filling approach and the authors have developed a data-driven tool, called GenRA, to support expert-driven RAX. This work describes a stand-alone Python...
Search relevance: 142.92 | Views last month: 1 -
G. Patlewicz, P. Karamertzanis, K. Paul Friedman, M. Sannicola, I. Shah, A systematic analysis of read-across within REACH registration dossiers, Computational Toxicology, Volume 30, 2024, 100304,...
Search relevance: 132.97 | Views last month: 0 -
Dataset for "Development of a CSRML version of the Analog Identification Methodology (AIM) fragments and their evaluation within the Generalised Read-Across (GenRA) approach.”. This dataset is...
Search relevance: 118.90 | Views last month: 0 -
This repository contains code, input and output files associated with the GenRA acute toxicity case study that was published by Helman et al (2019) in Computational Toxicology. This dataset is...
Search relevance: 108.96 | Views last month: 0 -
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although much technical guidance is...
Search relevance: 103.82 | Views last month: 0 -
The dataset contains the outputs for the analogue searches conducted for the chemical of interest, p,p'-DDD. This dataset is associated with the following publication: Lizarraga, L., J. Dean, J....
Search relevance: 95.39 | Views last month: 0 -
Bioactivity data for p,p'-DDD and analogues from ToxCast assays conducted in liver cells were sourced from the EPA’s CompTox Chemistry Dashboard. The links also provide access to the ToxCast assay...
Search relevance: 91.28 | Views last month: 0 -
ToxCast bioactivity data and model predictions for the ER and AR pathways for p,p'-DDD and analogues
ToxCast bioactivity data and model predictions for the estrogen receptor (ER) and androgen receptor (AR) pathways were obtained from the inks provided. This dataset is associated with the...
Search relevance: 91.26 | Views last month: 1 -
Data for the exposure-response arrays comparing effect levels for non-cancer and cancer endpoints for p,p'-DDD and analogues were sourced from the links provided. This dataset is associated with...
Search relevance: 90.67 | Views last month: 0 -
Here are all of the data files used for this manuscript. Please note that this is all published data. Imran Shah 1.1060+ Chemicals and Chemical controls 2. Chemical descriptors (chm): 2048 Morgan...
Search relevance: 82.47 | Views last month: 2 -
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of the matrix, read-across of the...
Search relevance: 76.58 | Views last month: 0 -
t is widely accepted that substances that cannot penetrate through the skin will not be sensitizers. LogKow and molecular weight (MW) have been used to set thresholds for sensitization potential....
Search relevance: 59.24 | Views last month: 1 -
Data processing was conducted using the Anaconda distribution of Python 3.9 and associated libraries. Jupyter notebooks are available at https://github.com/patlewig/nts_pfas. Datasets supporting...
Search relevance: 58.17 | Views last month: 3 -
The original contributions presented in the study are included in the article and online through the TAME Toolkit, available at: https://uncsrp.github.io/Data-Analysis-Training-Modules/, with...
Search relevance: 57.82 | Views last month: 3 -
Data and code for "Grace Patlewicz, Ann M. Richard, Antony J. Williams, Richard S. Judson, Russell S. Thomas, Towards reproducible structure-based chemical categories for PFAS to inform and...
Search relevance: 57.20 | Views last month: 0 -
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational models on high-throughput...
Search relevance: 56.53 | Views last month: 8
