• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to rheumatoid arthritis (RA). We...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Circulating CD8+ CD28- T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 ± 17.7% versus 18.6 ± 7.6%). The level of...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Simponi (golimumab) is a prescription medication manufactured by Janssen Biotech, Inc., used as a tumor necrosis factor (TNF) blocker to treat inflammatory conditions like rheumatoid arthritis,...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Our goal in the present work was to determine whether male patients with untreated hypogonadism have an increased risk of developing rheumatic/autoimmune disease (RAD), and, if so, whether there...

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