Found 20 datasets matching "apoptosis-signaling".
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Background Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked immunodeficiency in...
Search relevance: 72.97 | Views last month: 0 -
Recent advances in methodology have made phosphopeptide analysis a tractable problem for many proteomicists. There are now a wide variety of robust and inexpensive enrichment strategies to...
Search relevance: 70.55 | Views last month: 0 -
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt,...
Search relevance: 69.31 | Views last month: 0 -
Background STAT3 phosphorylation is associated with the neoplastic state in many types of cancer, including prostate cancer. We investigated the role of IL-6 signaling and...
Search relevance: 67.39 | Views last month: 0 -
Mitochondrial DNA-depleted human skin fibroblasts (HSF rho0) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of 2100 nuclear genes encoding...
Search relevance: 64.22 | Views last month: 0 -
The functional genomic response of developing embryonic submandibular glands to NF-kappaB inhibition
Background The proper balance between epithelial cell proliferation, quiescence, and apoptosis during development is mediated by the specific temporal and spatial appearance of...
Search relevance: 63.63 | Views last month: 1 -
Background The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-conjugated bile acids are...
Search relevance: 61.90 | Views last month: 0 -
The lung is the product of a set of complex developmental interactions between two distinct tissues, the endodermally derived epithelium and the mesoderm. Each tissue contributes to lung...
Search relevance: 57.85 | Views last month: 0 -
A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the criteria for differential...
Search relevance: 57.20 | Views last month: 0 -
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are...
Search relevance: 56.54 | Views last month: 0 -
Background Xanthurenic acid is an endogenous product of tryptophan degradation by indoleamine 2,3-dioxygenase (IDO). We have previously reported that IDO is present in mammalian lenses,...
Search relevance: 56.51 | Views last month: 0 -
Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic...
Search relevance: 55.70 | Views last month: 0 -
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading...
Search relevance: 52.39 | Views last month: 0 -
Hypospadias is a developmental defect of urethral tube closure that has a complex etiology involving genetic and environmental factors, including anti-androgenic and estrogenic disrupting...
Search relevance: 51.09 | Views last month: 0 -
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading...
Search relevance: 51.09 | Views last month: 0 -
Background Hypertensive nephrosclerosis is the second most common cause of end-stage renal failure in the United States. The mechanism by which hypertension produces renal failure is...
Search relevance: 50.55 | Views last month: 0 -
Cartilage serves multiple functions in the developing embryo and in postnatal life. Genetic mutations affecting cartilage development are relatively common and lead to skeletal malformations,...
Search relevance: 50.49 | Views last month: 1 -
Multiplex ELisa data, MTF-1 and western blot. This dataset is associated with the following publication: Bruno, M., J. Ross, and Y. Ge. Proteomic Responses of BEAS-2B Cells to Nontoxic and Toxic...
Search relevance: 49.83 | Views last month: 0 -
There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years,...
Search relevance: 47.91 | Views last month: 0 -
The health risk from spaceflight-induced neuronal damage and potential adverse neurovascular effects is a chief concern. More recently, it has been proposed that neuroinflammatory response plays...
Search relevance: 46.78 | Views last month: 0
