• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The existence of psoriatic arthritis as a distinct clinical entity remains a topic of debate; some authors propose that it is simply the co-occurrence of psoriasis and inflammatory arthritis....

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-29

We are delighted to welcome you to the first printed issue ofArthritis Research, a publication that has already existed on the Internet for the last few months. This fact alone is an indication...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Because angiogenesis plays a major role in the perpetuation of inflammatory arthritis, we explored a method for selectively targeting and destroying new synovial blood vessels. Mice with...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line?

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures, which resemble secondary lymphoid organs....

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A possible cause of joint destruction in septic arthritis

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked...

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