Found 8 datasets matching "asthma-pathogenesis".
-
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of...
Search relevance: 106.86 | Views last month: 0 -
Asthma is the most common chronic childhood disease in the developed nations, and is a complex disease that has high social and economic costs. Studies of the genetic etiology of asthma offer a...
Search relevance: 74.50 | Views last month: 0 -
Chronic airway inflammation is one of the main features of asthma. Release of mediators from infiltrating inflammatory cells in the airway mucosa has been proposed to contribute directly or...
Search relevance: 73.09 | Views last month: 0 -
Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2...
Search relevance: 65.01 | Views last month: 0 -
This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process...
Search relevance: 61.97 | Views last month: 0 -
Th2 cytokines and asthma: an introduction
Search relevance: 58.81 | Views last month: 0 -
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a...
Search relevance: 58.42 | Views last month: 0 -
Over the past decade there has been a significant shift to the use of murine models for investigations into the molecular basis of respiratory diseases, including asthma and chronic obstructive...
Search relevance: 55.85 | Views last month: 0
