Found 20 datasets matching "cardiovascular-trials".
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Research Article: Current Controlled Trials in Cardiovascular Medicine
Search relevance: 250.14 | Views last month: 0 -
Some problems with the quality of controlled clinical trials can be addressed by following these procedures: registering all trials at inception; using systematic reviews to inform the design of...
Search relevance: 162.85 | Views last month: 1 -
The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was...
Search relevance: 118.08 | Views last month: 0 -
Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein (HDL)-cholesterol. Two secondary...
Search relevance: 106.69 | Views last month: 1 -
Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials...
Search relevance: 68.42 | Views last month: 1 -
In one of the biggest dilemmas facing cardiovascular clinical research, clinical trials are increasingly being required to show benefits on clinical end-points rather than surrogate end-points,...
Search relevance: 64.77 | Views last month: 0 -
Whether it matters how pressure is lowered has been debated since antihypertensive drugs proved to prevent cardiovascular events. However, in clinical trials, while the stroke benefit predicted by...
Search relevance: 60.20 | Views last month: 1 -
Large numbers of observational studies have described a decrease in the incidence of cardiovascular disease in women taking hormone replacement therapy (HRT). The potential mechanisms for this...
Search relevance: 60.09 | Views last month: 0 -
Background Antioxidant supplementation with vitamin E had no effect in the prevention of cardiovascular diseases (CVD) in three recent large, randomized clinical trials. In order to...
Search relevance: 57.84 | Views last month: 0 -
Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials...
Search relevance: 57.79 | Views last month: 0 -
The key question in hypertension research today is, "Does it matter how elevated blood pressure is lowered?" The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial...
Search relevance: 54.15 | Views last month: 1 -
Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?
Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials show no such benefit, however,...
Search relevance: 54.13 | Views last month: 0 -
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to...
Search relevance: 52.31 | Views last month: 2 -
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and...
Search relevance: 51.35 | Views last month: 0 -
Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid...
Search relevance: 51.01 | Views last month: 1 -
Cell transplantation to repair or regenerate injured myocardium is a new frontier in the treatment of cardiovascular disease. Even though it is based on many years of pre-clinical studies, much...
Search relevance: 50.58 | Views last month: 2 -
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major...
Search relevance: 48.54 | Views last month: 0 -
Background Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published about the various...
Search relevance: 44.88 | Views last month: 0 -
Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different...
Search relevance: 40.00 | Views last month: 0 -
The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown that the benefits...
Search relevance: 38.71 | Views last month: 1
