• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused a short-lasting, florid...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood coagulation. TF expression on monocytes and endothelial cells is induced by exposure to endotoxin, tumor...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A possible cause of joint destruction in septic arthritis

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including arthritis. In the present study, we examined...

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