Found 15 datasets matching "cell-growth-inhibition".
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Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt,...
Search relevance: 91.30 | Views last month: 0 -
The matricellular protein thrombospondin 2 (TSP2) regulates a variety of cell–matrix interactions. A prominent feature of TSP2-null mice is increased microvascular density, particularly in...
Search relevance: 89.63 | Views last month: 0 -
Background The tryptophan catabolizing enzyme, indoleamine 2,3, dioxygenase (IDO) is one of two mammalian enzymes, which can catabolize the rarest essential amino acid, tryptophan. IDO...
Search relevance: 87.20 | Views last month: 0 -
Background Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human...
Search relevance: 76.17 | Views last month: 0 -
Both L-arginine supplementation and deprivation influence cell proliferation. The effect of high doses on tumours is determined by the optical configuration: L-arginine is stimulatory, D-arginine...
Search relevance: 69.22 | Views last month: 1 -
Background Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically altered cells due to the...
Search relevance: 68.14 | Views last month: 0 -
The present invention provides compositions and methods for increasing therapeutic gain in radiotherapy and chemotherapy for proliferating malignant or nonmalignant disease to produce high...
Search relevance: 65.03 | Views last month: 0 -
Background The brine shrimp lethality assay is considered a useful tool for preliminary assessment of toxicity. It has also been suggested for screening pharmacological activities in...
Search relevance: 62.17 | Views last month: 1 -
Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation...
Search relevance: 57.32 | Views last month: 0 -
Background Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the...
Search relevance: 54.30 | Views last month: 0 -
Background Previous work, by us and others, has shown that mammalian galectins-1 have a growth-inhibitory activity for mammalian cells which is apparently independent of their...
Search relevance: 53.89 | Views last month: 0 -
Background Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts...
Search relevance: 53.65 | Views last month: 0 -
The functional genomic response of developing embryonic submandibular glands to NF-kappaB inhibition
Background The proper balance between epithelial cell proliferation, quiescence, and apoptosis during development is mediated by the specific temporal and spatial appearance of...
Search relevance: 53.21 | Views last month: 1 -
Background Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to...
Search relevance: 51.59 | Views last month: 0 -
The data set includes data for the development and testing for experiments that measure increases in amoxicillin resistance of bacterial mucus cultures. MIC (minimum inhibitory concentration) data...
Search relevance: 42.62 | Views last month: 0
