Found 8 datasets matching "clinical-heterogeneity".
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Objective To consider the problem of the calculation of number needed to treat (NNT) derived from risk difference, odds ratio, and raw pooled events shown to give different results using...
Search relevance: 114.61 | Views last month: 0 -
Background Current methodology often cannot distinguish second primary breast cancers from multifocal disease, a potentially important distinction for clinical management. In the present...
Search relevance: 56.83 | Views last month: 1 -
Background Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers...
Search relevance: 50.47 | Views last month: 1 -
The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The...
Search relevance: 49.72 | Views last month: 1 -
Genes in the human leukocyte antigen (HLA) region remain the most powerful disease risk genes in rheumatoid arthritis (RA). Several allelic variants of HLA-DRB1 genes have been associated with RA,...
Search relevance: 49.25 | Views last month: 0 -
Background Mild cognitive impairment (MCI) was recently described as a heterogeneous group with a variety of clinical outcomes and high risk to develop Alzheimer's disease (AD). Regional...
Search relevance: 45.91 | Views last month: 2 -
Background This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed...
Search relevance: 45.46 | Views last month: 1 -
Background Family history and twins studies suggest an inherited component to ischemic stroke risk. Candidate gene association studies have been performed but have limited capacity to...
Search relevance: 36.61 | Views last month: 0
