Found 69 datasets matching "clinical-trial".
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Background Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published about the various...
Search relevance: 193.55 | Views last month: 0 -
Background Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions...
Search relevance: 183.80 | Views last month: 1 -
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. ...
Search relevance: 147.17 | Views last month: 1 -
Background Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the treatment of rheumatoid arthritis (RA). Methods ...
Search relevance: 138.37 | Views last month: 1 -
Background The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous...
Search relevance: 117.51 | Views last month: 0 -
Data quality assurance and quality control are critical to the effective conduct of a clinical trial. In the present commentary, we discuss our experience in a large, multicenter stroke trial. In...
Search relevance: 115.32 | Views last month: 1 -
Introduction Treatment of sepsis is aimed at increasing both the duration and quality of survival. A long-term focus on quality of life (QoL) in clinical trial evaluations of sepsis care...
Search relevance: 112.28 | Views last month: 1 -
Some problems with the quality of controlled clinical trials can be addressed by following these procedures: registering all trials at inception; using systematic reviews to inform the design of...
Search relevance: 100.91 | Views last month: 1 -
Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials...
Search relevance: 99.11 | Views last month: 0 -
Background While a number of reviews of homeopathic clinical trials have been done, all have used methods dependent on allopathic diagnostic classifications foreign to homeopathic...
Search relevance: 98.39 | Views last month: 0 -
Background Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some researchers have found...
Search relevance: 97.88 | Views last month: 2 -
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide...
Search relevance: 88.73 | Views last month: 1 -
Introduction The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death...
Search relevance: 84.59 | Views last month: 0 -
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the...
Search relevance: 62.41 | Views last month: 1 -
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is a prospective, randomized, multicenter clinical trial of carotid endarterectomy (CEA) versus carotid artery stenting...
Search relevance: 62.24 | Views last month: 0 -
Background Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all...
Search relevance: 59.20 | Views last month: 0 -
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was...
Search relevance: 58.37 | Views last month: 3 -
Introduction Trials of complex health interventions often pose difficult methodologic challenges. The objective of this paper is to assess the extent to which the various development...
Search relevance: 57.93 | Views last month: 5 -
The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was...
Search relevance: 56.79 | Views last month: 0 -
This symposium provided a useful forum for the discussion of issues relating to the design and conduct of clinical trials. There is a need for greater awareness of the complexity of modern day...
Search relevance: 56.24 | Views last month: 0
