Found 6 datasets matching "cytotoxicity-study".
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Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated...
Search relevance: 130.58 | Views last month: 0 -
Background Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts...
Search relevance: 53.43 | Views last month: 0 -
Background Cholesterol oxides, the oxygenated derivatives of cholesterol, have been shown to cause programmed cell death in a variety of cell types. Using N9 microglia, this study was...
Search relevance: 40.21 | Views last month: 0 -
Background Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, δ-aminolevulinic acid (ALA) and...
Search relevance: 34.51 | Views last month: 0 -
In an effort to address a major challenge in chemical safety assessment, alternative approaches for characterizing systemic effect levels, a predictive model was developed. Systemic effect levels...
Search relevance: 34.25 | Views last month: 0 -
Background The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-conjugated bile acids are...
Search relevance: 32.95 | Views last month: 0
