Found 9 datasets matching "drug-metabolism".
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Background The search for an optimal experimental model in pharmacology is recently focused on (mini)pigs as they seem not only to be an alternative source of cells and tissues for...
Search relevance: 78.17 | Views last month: 0 -
Background Thyroid hormones are well known modulators of signal transduction. The effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase C (DAG/PKC) signaling in...
Search relevance: 72.63 | Views last month: 0 -
Data was generated at KUMC, not EPA. There is no EPA data that is part of this submission. This dataset is associated with the following publication: Liu, J., J.Y. Cui, Y. Lu, C. Corton, and C....
Search relevance: 51.52 | Views last month: 0 -
Pemetrexed is a prescription chemotherapy drug used to treat certain cancers, like non-small cell lung cancer and malignant pleural mesothelioma. It works by blocking folate metabolism in cancer...
Search relevance: 48.04 | Views last month: 0 -
The risks and benefits of stopping antiretroviral therapy in patients admitted to the ICU are largely unmeasured. In many cases therapy has to be stopped, as parenteral preparations are...
Search relevance: 40.17 | Views last month: 0 -
A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered....
Search relevance: 38.20 | Views last month: 0 -
Harsh environmental conditions including microgravity and radiation during prolonged spaceflights are known to alter hepatic metabolism. Our studies have focused on the analysis of possible...
Search relevance: 37.70 | Views last month: 0 -
The RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) study is a multinational, double-blind, randomized, placebo controlled trial which was recently published....
Search relevance: 32.26 | Views last month: 0 -
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
Search relevance: 30.77 | Views last month: 1
