Found 5 datasets matching "familial-cancer".
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In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were...
Search relevance: 148.88 | Views last month: 1 -
Background Mutations in BRCA1 and BRCA2 account for approximately 50% of breast cancer families with more than four affected cases, whereas exonic mutations in p53, PTEN, CHK2 and ATM...
Search relevance: 146.63 | Views last month: 0 -
Background We conducted the present study to determine whether breast cancer morphology is genetically determined. Methods Using the nationwide...
Search relevance: 118.34 | Views last month: 0 -
Background The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of...
Search relevance: 68.84 | Views last month: 3 -
Background Multiple endocrine neoplasias type 2A (MEN 2A) is a dominantly inherited cancer syndrome. Missence mutations in the codon encoding cysteine 634 of the ret proto-oncogene have...
Search relevance: 48.11 | Views last month: 0
