Found 10 datasets matching "homologous-recombination".
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Background Recent progress in insect transgenesis has been dramatic but existing transposon-based approaches are constrained by position effects and potential instability. Gene targeting...
Search relevance: 263.39 | Views last month: 0 -
Background Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and duplications,...
Search relevance: 158.25 | Views last month: 1 -
Background The moss Physcomitrella patens is an attractive model system for plant biology and functional genome analysis. It shares many biological features with higher plants but has...
Search relevance: 141.83 | Views last month: 0 -
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51...
Search relevance: 77.71 | Views last month: 0 -
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51...
Search relevance: 77.71 | Views last month: 0 -
Background Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability of...
Search relevance: 60.05 | Views last month: 0 -
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both position effects...
Search relevance: 55.84 | Views last month: 0 -
Mitotic death is a delayed response of p53 mutant tumours that are resistant to genotoxic damage. Questions surround why this response is so delayed and how its mechanisms serve a survival...
Search relevance: 49.75 | Views last month: 0 -
Background Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause...
Search relevance: 41.43 | Views last month: 0 -
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the suppression of transcripts that...
Search relevance: 35.19 | Views last month: 0
