Found 28 datasets matching "kinase-activity".
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Background Nitrogen fixation gene expression in Sinorhizobium meliloti, the alfalfa symbiont, depends on a cascade of regulation that involves both positive and negative control. On top...
Search relevance: 132.80 | Views last month: 0 -
An apoptosis inducing protein (ASK1) or derivatives thereof, having a protein kinase activity and enhancing an SEK1 kinase activity and/or MKK3 kinase activity; a base sequence encoding the same;...
Search relevance: 77.41 | Views last month: 0 -
Background The mos proto-oncogene encodes a cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division in vertebrates. Based on oncogenic...
Search relevance: 65.66 | Views last month: 0 -
Background The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53...
Search relevance: 62.26 | Views last month: 0 -
The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed...
Search relevance: 59.93 | Views last month: 0 -
Background Helicobacter pylori is the main risk factor for the development of non-cardia gastric cancer. Increased proliferation of the gastric mucosa is a feature of H. pylori...
Search relevance: 59.12 | Views last month: 0 -
Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation...
Search relevance: 56.29 | Views last month: 0 -
Background Activation of human resting T lymphocytes results in an immediate increase in protein synthesis. The increase in protein synthesis after 16–24 h has been linked to the...
Search relevance: 55.01 | Views last month: 0 -
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular...
Search relevance: 54.70 | Views last month: 0 -
Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase...
Search relevance: 54.51 | Views last month: 0 -
The 97th American Thoracic Society meeting proved to be an excellent meeting, providing a wealth of new information on inflammatory diseases of the airways. Once again there appeared to be an...
Search relevance: 52.52 | Views last month: 0 -
Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this...
Search relevance: 51.13 | Views last month: 0 -
Background Serotonin (5-HT, 5-hydroxytryptamine) activates the Extracellular Signal-Regulated Kinase (ERK)/ Mitogen-Activated Protein Kinase (MAPK) pathways, in vascular smooth muscle...
Search relevance: 48.44 | Views last month: 0 -
Background Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions....
Search relevance: 48.27 | Views last month: 0 -
Background In S. cerevisiae, the mitotic exit network (MEN) proteins, including the Polo-like protein kinase Cdc5 and the protein phosphatase Cdc14, are required for exit from mitosis....
Search relevance: 45.48 | Views last month: 0 -
Background Vaccinia virus gene B1R encodes a serine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R,...
Search relevance: 45.30 | Views last month: 0 -
Background Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer...
Search relevance: 44.55 | Views last month: 0 -
Background Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling...
Search relevance: 41.62 | Views last month: 0 -
Background The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous...
Search relevance: 41.46 | Views last month: 0
