• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the β-actin gene as a...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Circulating levels of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) have been associated with outcome in solid and hematologic malignancies. Within the TNF gene and the...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using spleen DNA from CBA mice which...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using spleen DNA from CBA mice which...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides. ...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The signal transduction pathways mediated by retinoic acid play a critical role in the regulation of cell growth and differentiation during embryogenesis and hematopoiesis as...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Nilotinib is a prescription oral capsule medication used to treat certain types of leukemia, such as chronic myeloid leukemia. It works as a kinase inhibitor, targeting specific enzymes involved...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Mercaptopurine is an oral suspension prescription drug that inhibits nucleic acid synthesis, used to treat certain cancers like leukemia. It comes in a 20 mg/mL strength, manufactured by Hikma...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Myleran (busulfan) is an oral tablet used as chemotherapy to treat certain blood cancers like chronic myeloid leukemia. It works by damaging cancer cells' DNA. Each tablet contains 2 mg of...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Idhifa (enasidenib mesylate) is a prescription oral tablet that inhibits the IDH2 enzyme, used to treat adults with relapsed or refractory acute myeloid leukemia (AML) who have an IDH2 mutation....

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Imatinib Mesylate is a generic prescription oral tablet medication that inhibits certain enzymes to treat conditions like chronic myeloid leukemia and gastrointestinal stromal tumors. Available in...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Bendamustine Hydrochloride is a generic prescription drug, available as an injectable powder in 25 mg and 100 mg vials, administered intravenously. It's an alkylating agent used to treat certain...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-07-23

Prospective Payment System (PPS)-Exempt Cancer Hospital Quality Reporting (PCHQR) Complications and Unplanned Hospital Visits. This dataset evaluates the percentage of patients who are receiving...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Clofarabine is an intravenous injection used to treat relapsed or refractory acute lymphoblastic leukemia, particularly in pediatric patients. It belongs to the class of nucleoside metabolic...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Decitabine is an intravenous prescription drug used to treat certain blood disorders like myelodysplastic syndromes and acute myeloid leukemia. It comes as a lyophilized powder in 50 mg vials,...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-07-23

Prospective Payment System (PPS)-Exempt Cancer Hospital Quality Reporting (PCHQR) Complications and Unplanned Hospital Visits. This dataset evaluates the percentage of patients who are receiving...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Besponsa (inotuzumab ozogamicin) is an intravenous prescription drug, supplied as a lyophilized powder for injection. It's an immunoconjugate that targets CD22 on cancer cells, leading to DNA...

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