Found 50 datasets matching "macrophages".
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Background Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a...
Search relevance: 141.05 | Views last month: 0 -
In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly implicated in directing the...
Search relevance: 134.19 | Views last month: 0 -
The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the...
Search relevance: 119.28 | Views last month: 0 -
Mycobacterium aviumsubspeciesparatuberculosis(M. paratuberculosis) is a facultative intracellular pathogen that resides within host macrophages during infection of ruminant animals. We examined...
Search relevance: 114.99 | Views last month: 0 -
Background T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting...
Search relevance: 114.81 | Views last month: 0 -
Background The effect of silicones on the immune function is not fully characterized. In clinical and experimental studies, immune alterations associated with silicone gel seem to be...
Search relevance: 100.07 | Views last month: 0 -
Background Macrophages, upon encounter with micro-organisms or stimulated by cytokines, produce various effector molecules aimed at destroying the foreign agents and protecting the...
Search relevance: 99.68 | Views last month: 0 -
Cell investigation into mechanism of particle-related biological effect. This dataset is associated with the following publication: Ghio, A., J. Soukup, J. Stonehuerner , H. Tong, J. Richards,...
Search relevance: 92.52 | Views last month: 0 -
Background: Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung injury. This study was designed to investigate...
Search relevance: 91.37 | Views last month: 0 -
We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused a short-lasting, florid...
Search relevance: 83.14 | Views last month: 0 -
Background Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in...
Search relevance: 79.33 | Views last month: 0 -
Background Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated...
Search relevance: 76.65 | Views last month: 0 -
Background Lysosomes are acidic organelles that play multiple roles in various cellular oxidative activities such as the oxidative burst during cytotoxic killing. It remains to be...
Search relevance: 65.67 | Views last month: 0 -
Background Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present...
Search relevance: 53.03 | Views last month: 0 -
Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages...
Search relevance: 49.78 | Views last month: 0 -
Background The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause tuberculosis. To...
Search relevance: 45.10 | Views last month: 0 -
IL-10 is an anti-inflammatory cytokine produced in the joint in rheumatoid arthritis by macrophages and infiltrating blood lymphocytes. Regulation of its expression is poorly understood, but...
Search relevance: 44.58 | Views last month: 0 -
We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle Space Transportation System...
Search relevance: 43.66 | Views last month: 1 -
The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The...
Search relevance: 43.04 | Views last month: 0 -
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important...
Search relevance: 40.88 | Views last month: 0
