Found 41 datasets matching "mechanisms of action".
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Background Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the...
Search relevance: 94.14 | Views last month: 0 -
Various Cmap analyses within and across species and microarray platforms conducted and summarized to generate the tables in the publication. This dataset is associated with the following...
Search relevance: 53.73 | Views last month: 1 -
A break-open action for sporting rifles comprising a forward part for connection with the at least one rifle barrel, which part can be releasably locked together with a rearward part by snug seats...
Search relevance: 53.01 | Views last month: 1 -
RLWrankedLists.tar.gz:These lists linked to various chemical treatment conditions serve as the target collection of Cmap. Probes of the entire microarray are sorted based on their log fold...
Search relevance: 51.81 | Views last month: 0 -
The maximum connectivity scores of pairwise chemical conditions summarized from Cmap results in a file with Cytoscape format (http://www.cytoscape.org/). The figures in the publication were...
Search relevance: 51.38 | Views last month: 0 -
data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright,...
Search relevance: 49.87 | Views last month: 0 -
Voids form as a consequence of the deteriorated state or poor design of the structures they are associated with. There are a variety of different mechanisms that can lead to the formation of...
Search relevance: 46.18 | Views last month: 0 -
The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling...
Search relevance: 45.91 | Views last month: 1 -
This study examined effects of the brominated flame retardant hexabromocyclododecane (HBCD) on the avian endocrine system. Japanese quail (Coturnix japonica) were exposed to multiple doses of HBCD...
Search relevance: 45.79 | Views last month: 0 -
Background Parkinson's disease is caused by a dopamine deficiency state in the fore brain area. Dopamine receptor agonists, MAO-B inhibitors, and N-Methyl-D-Aspartate (NMDA) receptor...
Search relevance: 44.97 | Views last month: 0 -
Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human...
Search relevance: 43.19 | Views last month: 0 -
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). One current...
Search relevance: 42.32 | Views last month: 0 -
Background One of the earliest steps in synaptogenesis at the neuromuscular junction is the aggregation of nicotinic acetylcholine receptors at the postsynaptic membrane. This study...
Search relevance: 35.67 | Views last month: 0 -
Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density...
Search relevance: 34.77 | Views last month: 0 -
Background As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold: (1) to fractionate crude extracts from the...
Search relevance: 34.16 | Views last month: 0 -
Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in the formation...
Search relevance: 33.59 | Views last month: 1 -
Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can...
Search relevance: 33.20 | Views last month: 0 -
Amphibians are vulnerable to extinction owing, partly, to altered physiological processes induced by projected global warming and drying. Understanding the mechanisms behind their responses is...
Search relevance: 29.85 | Views last month: 0 -
Background Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope...
Search relevance: 29.58 | Views last month: 0 -
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
Search relevance: 28.02 | Views last month: 1
