Found 9 datasets matching "mechanistic toxicology".
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Supplementary Files 1-15 contain the generated assay data that was used to establish BMAD and determine treatment effects. The tabbed spreadsheet data is formatted so that it can be directly...
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This dataset contains in vitro and in vivo biochemical and apical (i.e., growth/development) data pertaining to iodotyrosine deiodinase inhibition in the African clawed frog (Xenopus laevis)....
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Dataset for Harrill, J.A. et al., 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping' published in Toxicological Sciences,...
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This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR) assays, to examine the mechanistic...
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Our ability to conduct whole organism toxicity tests to understand chemical safety has been outpaced by our ability to synthesize new chemicals for a wide variety of commercial applications. ...
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We screened 44 chemicals in MCF7 cells in concentration response and generated HTTr data using the TempO-Seq hWTv1 assay. First, we provide an outline of the quality of the HTTr data based on a...
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The data presented here support the application of the Stemina devTOXqP platform for predictive toxicology and further demonstrate its value in ToxCast as a novel resource that can generate...
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Proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated, and evaluated by statistically evaluating data on all possible binary...
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We have previously shown that neuroendocrine activation leading to increased circulating stress hormones was necessary for mediating ozone-induced lung injury and inflammation since adrenalectomy...
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