Found 8 datasets matching "mhc-binding".
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Background Major histocompatibility complex (MHC) molecules present peptides to T lymphocytes. It is of critical biological and medical importance to elucidate how different MHC alleles...
Search relevance: 260.17 | Views last month: 1 -
Background Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class...
Search relevance: 225.10 | Views last month: 1 -
Background Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of...
Search relevance: 203.11 | Views last month: 0 -
Background Quantitative information on the types of inter-atomic interactions at the MHC-peptide interface will provide insights to backbone/sidechain atom preference during binding....
Search relevance: 150.81 | Views last month: 0 -
There is provided a tolerogenic human peptide, capable of binding to an MHC class I or II molecule without further antigen processing, for use in the treatment and/or prevention of multiple...
Search relevance: 73.60 | Views last month: 0 -
T-cell epitopes represent sampled environmental- and self-peptides loaded into major histocompatibility complex (MHC) proteins. Bioinformatic tools have been produced to predict these interactions...
Search relevance: 59.46 | Views last month: 0 -
A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more...
Search relevance: 53.58 | Views last month: 0 -
Background Mesenchymal-epithelial interactions play an important role in the physiology and pathology of epithelial tissues. Mesenchymal cells either associate with epithelium basement...
Search relevance: 41.43 | Views last month: 1
