Found 11 datasets matching "mutational-analysis".
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Human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia virus type II (HTLV-2) use a similar mechanism for –1 translational frameshifting to overcome the termination codon in ...
Search relevance: 193.07 | Views last month: 0 -
Background Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P2). Crystallography, NMR and...
Search relevance: 88.79 | Views last month: 0 -
Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre
Background Multinodular goitre (MNG) is a common disorder characterised by an enlargement of the thyroid, occurring as a compensatory response to hormonogenesis impairment. The incidence...
Search relevance: 85.19 | Views last month: 0 -
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of...
Search relevance: 55.13 | Views last month: 1 -
In the present study 55 IgVH genes amplified from three different anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding further information on synovial B-cell...
Search relevance: 47.98 | Views last month: 0 -
Patients with Sjögren's syndrome (SS) have characteristic lymphocytic infiltrates of the salivary glands. To determine whether the B cells accumulating in the salivary glands of SS patients...
Search relevance: 46.50 | Views last month: 0 -
Background The tropomodulins (TMODs) are a family of proteins that cap the pointed ends of actin filaments. Four TMODs have been identified in humans, with orthologs in mice. Mutations...
Search relevance: 41.16 | Views last month: 1 -
Background Two-component systems consisting of histidine kinases and their corresponding receivers are widespread in bacterial signal transduction. In the past few years, genes coding...
Search relevance: 40.86 | Views last month: 0 -
Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the...
Search relevance: 40.09 | Views last month: 0 -
Background: Uracil DNA glycosylases (UDGs) are major repair enzymes that protect DNA from mutational damage caused by uracil incorporated as a result of a polymerase error or deamination...
Search relevance: 35.96 | Views last month: 0 -
Background Mutations in the fibrillin -1 gene (FBN1) cause Marfan syndrome (MFS), an autosomal dominant multi-system connective tissue disorder. The 200 different mutations reported in...
Search relevance: 33.89 | Views last month: 0
