Found 26 datasets matching "osteoarthritis".
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Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective...
Search relevance: 156.01 | Views last month: 0 -
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation;...
Search relevance: 145.57 | Views last month: 1 -
During our careers, we have developed new and innovative concepts pertaining to the pathophysiology of osteoarthritis which have assisted in the development of new therapeutic approaches....
Search relevance: 138.01 | Views last month: 0 -
Clinical practice guidelines are important tools to assist clinical decision-making. Recently, several guidelines addressing the management of osteoarthritis (OA) have been published. Clinicians...
Search relevance: 129.77 | Views last month: 0 -
Hip osteoarthritis (OA) is a degenerative joint disease that results in substantial morbidity. The disease may be preventable in some instances by reducing risk factors associated with the...
Search relevance: 128.24 | Views last month: 3 -
Background The purpose of this study was to compare the efficacy of electroacupuncture (EA), diclofenac and their combination in symptomatic treatment of osteoarthritis (OA) of the...
Search relevance: 112.58 | Views last month: 0 -
Background It has been reported that there is an inverse association between osteoarthritis (OA) and osteoporosis. However, the relationship of bone mass to OA in a Japanese population...
Search relevance: 111.14 | Views last month: 0 -
Background Osteoarthritis (OA) of the knee, which is prevalent among older adults in nursing homes, causes significant pain and suffering, including disturbance of nocturnal sleep. One...
Search relevance: 106.11 | Views last month: 1 -
Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial fibroblasts (SFB; 98% enrichment;...
Search relevance: 103.85 | Views last month: 0 -
Rheumatoid arthritis (RA) patients experience a markedly increased frequency of cardiovascular disease. We evaluated cardiovascular risk profiles in 79 RA patients and in 39 age-matched and...
Search relevance: 89.25 | Views last month: 0 -
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III,...
Search relevance: 64.90 | Views last month: 0 -
Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries....
Search relevance: 60.21 | Views last month: 0 -
Angiopoietins (Ang) are vascular endothelial cell-specific growth factors that play important roles principally during the later stages of angiogenesis. We have compared the distribution of the...
Search relevance: 57.18 | Views last month: 0 -
Osteoporosis (OP) and osteoarthritis (OA), the two most common age-related chronic disorders of articular joints and skeleton, represent a major public health problem in most developed countries....
Search relevance: 56.57 | Views last month: 1 -
Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result...
Search relevance: 54.65 | Views last month: 0 -
Diclofenac Sodium is a prescription topical gel containing 3% diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID). It's applied to the skin to help reduce pain and swelling from...
Search relevance: 40.61 | Views last month: 0 -
Diclofenac Sodium 1.5% is a prescription topical solution used to relieve pain and inflammation from conditions like osteoarthritis. It contains diclofenac sodium, a non-steroidal...
Search relevance: 39.90 | Views last month: 0 -
This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process...
Search relevance: 35.83 | Views last month: 0 -
Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and...
Search relevance: 34.40 | Views last month: 0 -
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth...
Search relevance: 33.61 | Views last month: 0
