Found 18 datasets matching "proteases".
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The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of...
Search relevance: 160.32 | Views last month: 0 -
Background Mechanisms regulating neuronal migration during development remain largely undefined. Extracellular matrix cues, target site released factors, and components of the migratory...
Search relevance: 87.16 | Views last month: 0 -
While many proteases in articular cartilage have been described, current studies indicate that members of two families of metalloproteases – MMPs and the ADAMTSs – are responsible for the...
Search relevance: 82.42 | Views last month: 0 -
Background This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases...
Search relevance: 58.95 | Views last month: 0 -
The HIV Protease Structural Database is an archive of experimentally determined 3-D structures of Human Immunodeficiency Virus 1 (HIV-1), Human Immunodeficiency Virus 2 (HIV-2) and Simian...
Search relevance: 42.88 | Views last month: 0 -
The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to...
Search relevance: 39.18 | Views last month: 0 -
Background Exported proteases are commonly associated with virulence in bacterial pathogens, yet there is a paucity of information regarding their role in Mycobacterium tuberculosis....
Search relevance: 37.39 | Views last month: 0 -
Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result...
Search relevance: 37.37 | Views last month: 0 -
Background The genome of Mycobacterium tuberculosis H37Rv has five copies of a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 (lhp) and ESAT-6...
Search relevance: 36.21 | Views last month: 0 -
Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a...
Search relevance: 36.21 | Views last month: 0 -
Hepatitis C virus (HCV) is an important human pathogen that affects ∼100 million people worldwide. Its RNA genome codes for a polyprotein, which is cleaved by viral and cellular proteases to...
Search relevance: 34.61 | Views last month: 0 -
Background Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Drosophila...
Search relevance: 32.81 | Views last month: 0 -
Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor for opportunistic infections. Because of the potential threat of S. aureus to astronaut health, the effect...
Search relevance: 32.10 | Views last month: 0 -
Background The proteinase-activated receptor 4 (PAR4) is a G-protein-coupled receptor activated by proteases such as thrombin and trypsin. Although activation of PAR4 has been shown to...
Search relevance: 31.93 | Views last month: 0 -
Background One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Aβ, in the brain. Aβ arises from cleavage of the Amyloid Precursor protein by β...
Search relevance: 29.51 | Views last month: 1 -
Background A family of aspartate-specific cysteinyl proteases, named caspases, mediates programmed cell death, apoptosis. In this function, caspases are important for physiological...
Search relevance: 28.06 | Views last month: 0 -
Background The ubiquitin-dependent protein degradation pathway is essential for the proteolysis of intracellular proteins and peptides. Deubiquitinating enzymes constitute a complex...
Search relevance: 27.38 | Views last month: 0 -
Deep sequencing technologies were used to construct the first adult female Culicoides sonorensis reference transcriptome. Genetic and genomic tools for Culicoides biting midges are lacking,...
Search relevance: 16.37 | Views last month: 1
