Found 112 datasets matching "protein-function".
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Background Members of the p24 (p24/gp25L/emp24/Erp) family of proteins have been shown to be critical components of the coated vesicles that are involved in the transportation of cargo...
Search relevance: 134.52 | Views last month: 0 -
Background Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of...
Search relevance: 92.43 | Views last month: 0 -
Background We present a simple method to train a potential function for the protein folding problem which, even though trained using a small number of proteins, is able to place a...
Search relevance: 92.11 | Views last month: 0 -
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the...
Search relevance: 87.11 | Views last month: 0 -
Background: Standard archival sequence databases have not been designed as tools for genome annotation and are far from being optimal for this purpose. We used the database of Clusters...
Search relevance: 72.21 | Views last month: 0 -
Background: Protein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an important biological...
Search relevance: 55.88 | Views last month: 0 -
Background The L-type Ca2+ channel formed by the dihydropyridine receptor (DHPR) of skeletal muscle senses the membrane voltage and opens the ryanodine receptor (RyR1). This...
Search relevance: 54.05 | Views last month: 0 -
A new way to rapidly create functional, fluorescent fusion proteins: random insertion of GFP with an
Background The jellyfish green fluorescent protein (GFP) can be inserted into the middle of another protein to produce a functional, fluorescent fusion protein. Finding permissive sites...
Search relevance: 53.61 | Views last month: 1 -
Background The ubiquitin-dependent protein degradation pathway is essential for the proteolysis of intracellular proteins and peptides. Deubiquitinating enzymes constitute a complex...
Search relevance: 53.12 | Views last month: 0 -
A collection of Reference Sequence (RefSeq) proteins, from the complete genomes of prokaryotes, plasmids, and organelles, that have been grouped and annotated based on sequence similarity and...
Search relevance: 52.67 | Views last month: 0 -
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss in muscle force...
Search relevance: 52.57 | Views last month: 0 -
Background Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein...
Search relevance: 52.48 | Views last month: 0 -
Background The genetic code is known to be efficient in limiting the effect of mistranslation errors. A misread codon often codes for the same amino acid or one with similar biochemical...
Search relevance: 52.03 | Views last month: 0 -
Background: Cohesin is a macromolecular complex that links sister chromatids together at the metaphase plate during mitosis. The links are formed during DNA replication and destroyed...
Search relevance: 51.93 | Views last month: 0 -
This is a file containing aggregation data for two proteins that were thermomechanically aggregated. The aggregated proteins were separated by asymmetric flow field flow fractionation and...
Search relevance: 51.40 | Views last month: 0 -
This is a file containing aggregation data for two proteins that were thermomechanically aggregated. The aggregated proteins were separated by asymmetric flow field flow fractionation and...
Search relevance: 51.40 | Views last month: 0 -
Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a...
Search relevance: 51.17 | Views last month: 0 -
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of...
Search relevance: 50.85 | Views last month: 1 -
Background Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative rates test in an...
Search relevance: 50.62 | Views last month: 0
