Found 16 datasets matching "retinoic-acid".
-
Background Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the...
Search relevance: 212.82 | Views last month: 0 -
Background Several Retinoic Acid Receptors (RAR) agonists have therapeutic activity against a variety of cancer types; however, unacceptable toxicity profiles have hindered the...
Search relevance: 204.80 | Views last month: 2 -
All trans retinoic acid (ATRA) is a potent inducer of differentiation of HL-60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl (HMG)...
Search relevance: 150.64 | Views last month: 0 -
Background Expression of the retinoic acid receptor β2 (RAR-β2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the...
Search relevance: 134.92 | Views last month: 1 -
Background The signal transduction pathways mediated by retinoic acid play a critical role in the regulation of cell growth and differentiation during embryogenesis and hematopoiesis as...
Search relevance: 129.44 | Views last month: 0 -
Background Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the...
Search relevance: 112.89 | Views last month: 0 -
We differentiated human induced pluripotent stem cells (hiPSCs) to embryonic endoderm and sought to identify a tipping point at which the developing system did not recover from perturbations...
Search relevance: 112.05 | Views last month: 0 -
We evaluated the Templated Oligo with Sequencing Readout (TempO-Seq) assay for High-throughput transcriptomic screening of a small set of environmental chemicals. This assay yields sequencing...
Search relevance: 101.58 | Views last month: 0 -
Background: The germ cell nuclear factor (GCNF, also known as retinoid acid receptor-related testis-associated receptor, neuronal cell nuclear receptor or NR6A1) is an orphan receptor in...
Search relevance: 64.49 | Views last month: 0 -
['To reveal the potential mechanisms involved in the dysfunction of antiviral immune responses under simulated microgravity conditions, we investigated the transcriptional changes related to the...
Search relevance: 62.79 | Views last month: 0 -
Background Retinoids are very potent inducers of cellular differentiation and apoptosis, and are efficient anti-tumoral agents. Synthetic retinoids are designed to restrict their...
Search relevance: 58.32 | Views last month: 0 -
Dataset for Sakamuru, S., Ma, D., Pierro, J. D., Baker, N. C., Kleinstreuer, N., Cali, J. J., Knudsen, T. B., & Xia, M. (2024). Development and validation of CYP26A1 inhibition assay for...
Search relevance: 57.52 | Views last month: 0 -
The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure for human-relevant AOPs and...
Search relevance: 50.00 | Views last month: 0 -
Organogenesis in the embryo involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the...
Search relevance: 44.20 | Views last month: 1 -
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from cellular alterations, we built a...
Search relevance: 39.81 | Views last month: 0 -
Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated...
Search relevance: 36.57 | Views last month: 3
