Found 15 datasets matching "small-molecules".
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The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the...
Search relevance: 105.90 | Views last month: 0 -
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The...
Search relevance: 54.69 | Views last month: 0 -
Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can...
Search relevance: 47.10 | Views last month: 0 -
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a...
Search relevance: 40.16 | Views last month: 0 -
In 2010, a mass mortality of pufferfish in Hawaii was dominated by Arothron hispidus showing aberrant neurological behaviors. Using pathology, toxinology, and field surveys, we implicated a...
Search relevance: 36.87 | Views last month: 0 -
The increasing amounts of discarded textiles represent a potentially valuable resource that could be reclaimed. This work underscores the significance of advancing chemical recycling techniques...
Search relevance: 35.24 | Views last month: 9 -
Background Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to...
Search relevance: 30.94 | Views last month: 0 -
Background We are investigating a double transgenic rat (dTGR) model, in which rats transgenic for the human angiotensinogen and renin genes are crossed. These rats develop moderately...
Search relevance: 29.89 | Views last month: 0 -
We documented the type two polyketide synthases(PKS II) gene diversity and novelty by sequencing KSα genes known to synthesize bioactive small molecules. Sequences were derived from culturable...
Search relevance: 28.34 | Views last month: 0 -
The stable fly, Stomoxys calcitrans L. (Diptera: Muscidae), is one of the most significant pests of livestock in the United States. The identification of targets for the development of novel...
Search relevance: 24.95 | Views last month: 0 -
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an...
Search relevance: 23.41 | Views last month: 0 -
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an...
Search relevance: 23.40 | Views last month: 0 -
Background: mRNA interactions with each other and other signaling molecules define different biological pathways and functions. Researchers have been investigating various tools to analyze these...
Search relevance: 22.26 | Views last month: 0 -
Biochars are charcoals used as soil amendments, and they have many beneficial effects on soil health. However, one negative effect is biochars often reduce concentrations of soil nitrogen that are...
Search relevance: 13.81 | Views last month: 0
