• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

To further development of our gene expression approach to biodosimetry we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Because of their ubiquity and resistance to spacecraft decontamination bacterial spores are considered likely potential forward contaminants on robotic missions to Mars. Thus it is important to...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Using diamagnetic levitation we have exposed A. thaliana in vitro callus cultures to five environments with different levels of effective gravity (from levitation i.e. simulated mg* to 2g*) and...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (uG). Immunosuppression during spaceflight is a major barrier to safe...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Using diamagnetic levitation we have exposed A. thaliana in vitro callus cultures to five environments with different levels of effective gravity (from levitation i.e. simulated mg* to 2g*) and...

• html

• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

To further development of our gene expression approach to biodosimetry we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to...

• html

• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety health and performance of the crewmembers. As a ubiquitous environmental...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The effect of microgravity on gene expression in C.elegans was comprehensively analysed by DNA microarray. This is the first DNA microarray analysis for C.elegans grown under microgravity. Hyper...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA developed ground based Rotary...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy) 1 and 4 weeks after exposure. Gene...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Changes in the physical environment modulate cell responses and may lead to the impairment or even failure of tissue function as a result of mechanotransduction processes. It has been suggested...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their osteogenic potential in a...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological samples here. Mice were exposed...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed on the International Space...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their osteogenic potential in a...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The existence of a radiation bystander effect in which non-irradiated cells respond to signals from irradiated cells is well established. It raises concerns for the interpretation of risks from...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This study demonstrates simulated microgravity effects on E. coli K 12 MG1655 when grown on LB medium supplemented with glycerol. The results imply that E. coli readily reprograms itself to combat...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

Radiation affects tissue and cellular integrity at the level of DNA protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

This study demonstrates simulated microgravity effects on E. coli K 12 MG1655 when grown on LB medium supplemented with glycerol. The results imply that E. coli readily reprograms itself to combat...

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