Found 11 datasets matching "xenobiotic metabolism".
-
With exception of metabolic simulations performed using TIMES (version 2.31.2.82), all work was performed using Python (version 3.10.4) run with IPython (version 8.4.0) in JupyterLab (version...
Search relevance: 215.82 | Views last month: 1 -
Dataset for Jurgelewicz, A. et al, 'Assessing the impact of in vitro xenobiotic metabolism on estrogenic chemical bioactivity in high-throughput profiling assays' published in Toxicology, Vol 517,...
Search relevance: 185.60 | Views last month: 0 -
Gene array data files compared gene expression profiles in liver samples from young (21-45 years) and old (69+ years) men and women to determine changes in the expression of xenobiotic metabolism...
Search relevance: 176.08 | Views last month: 1 -
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS) assays. However, existing HTS...
Search relevance: 71.42 | Views last month: 0 -
The objective of this study was to develop an approach to retrofit existing HTS assays with hepatic metabolism. The Alginate Immobilization of Metabolic Enzymes (AIME) platform encapsulates...
Search relevance: 58.86 | Views last month: 1 -
Understanding biotransformation pathways in aquatic species is an integral part of ecological risk assessment with respect to the potential bioactivation of chemicals to more toxic metabolites....
Search relevance: 58.33 | Views last month: 0 -
Data for Hopperstad K and Deisenroth C (2023) Development of a bioprinter-based method for incorporating metabolic competence into high-throughput in vitro assays. Front. Toxicol. 5:1196245. doi:...
Search relevance: 58.25 | Views last month: 0 -
This is an original dataset generated at the U.S. EPA. Data was analyzed with the ToxCast Pipeline and deposited for release in invitroDB accessible via the U.S. EPA CompTox Chemicals...
Search relevance: 57.30 | Views last month: 2 -
A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered....
Search relevance: 57.10 | Views last month: 0 -
Background: Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use and the thousands of environmental chemicals lacking toxicity...
Search relevance: 46.62 | Views last month: 6 -
In an effort to address a major challenge in chemical safety assessment, alternative approaches for characterizing systemic effect levels, a predictive model was developed. Systemic effect levels...
Search relevance: 34.91 | Views last month: 0
