A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg
In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly is more difficult to target two molecules (IL-1 α and β) than one (TNF-α). In his review article, Professor Wim van den Berg argues that both TNF-α and IL-1 must be blocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1. This commentary discusses his hypothesis in light of animal studies and the limitations of the conclusions that can be drawn from them. More broadly, it discusses the biology of TNF-α and IL-1 and suggests explanations of why TNF-α is a pivotal cytokine in this disease.
Complete Metadata
| @type | dcat:Dataset |
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[
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| description | In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly is more difficult to target two molecules (IL-1 α and β) than one (TNF-α). In his review article, Professor Wim van den Berg argues that both TNF-α and IL-1 must be blocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1. This commentary discusses his hypothesis in light of animal studies and the limitations of the conclusions that can be drawn from them. More broadly, it discusses the biology of TNF-α and IL-1 and suggests explanations of why TNF-α is a pivotal cytokine in this disease. |
| distribution |
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| identifier | https://healthdata.gov/api/views/a6er-36e2 |
| issued | 2025-07-14 |
| keyword |
[
"anti-tnf-therapy",
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| landingPage | https://healthdata.gov/d/a6er-36e2 |
| modified | 2025-09-06 |
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| publisher |
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| theme |
[
"NIH"
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|
| title | A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg |
