A fulvic acid-like substance participates in the pro-inflammatory effects of cigarette smoke and wood smoke particles
We tested the postulate that 1) a fulvic acid (FA)-like substance is included in cigarette smoke and wood smoke particles and 2) exposure of respiratory epithelial cells to this substance results in a disruption of iron homeostasis associated with both a cell deficiency of the metal and inflammatory response. It was concluded that 1) FA-like substance is included in cigarette smoke and wood smoke particle and 2) respiratory epithelial cell exposure to this substance results in a disruption of iron homeostasis associated with both a cell deficiency of the metal and inflammatory response.
This dataset is associated with the following publication:
Gonzalez, D., J. Soukup, M. Madden, M. Hays, J. Berntsen, S. Paulson, and A. Ghio. A fulvic acid-like substance participates in the pro-inflammatory effects of cigarette smoke and wood smoke particles.. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, USA, 33(4): 999-1009, (2020).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Andrew Ghio",
"hasEmail": "mailto:ghio.andy@epa.gov"
}
|
| description | We tested the postulate that 1) a fulvic acid (FA)-like substance is included in cigarette smoke and wood smoke particles and 2) exposure of respiratory epithelial cells to this substance results in a disruption of iron homeostasis associated with both a cell deficiency of the metal and inflammatory response. It was concluded that 1) FA-like substance is included in cigarette smoke and wood smoke particle and 2) respiratory epithelial cell exposure to this substance results in a disruption of iron homeostasis associated with both a cell deficiency of the metal and inflammatory response. This dataset is associated with the following publication: Gonzalez, D., J. Soukup, M. Madden, M. Hays, J. Berntsen, S. Paulson, and A. Ghio. A fulvic acid-like substance participates in the pro-inflammatory effects of cigarette smoke and wood smoke particles.. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, USA, 33(4): 999-1009, (2020). |
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|
| identifier | https://doi.org/10.23719/1504592 |
| keyword |
[
"air pollution"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-10-10 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
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}
|
| references |
[
"https://doi.org/10.1021/acs.chemrestox.0c00036"
]
|
| rights |
null
|
| title | A fulvic acid-like substance participates in the pro-inflammatory effects of cigarette smoke and wood smoke particles |
