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A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| accrualPeriodicity | irregular |
| bureauCode |
[
"026:00"
]
|
| contactPoint |
{
"fn": "GeneLab Outreach",
"@type": "vcard:Contact",
"hasEmail": "mailto:genelab-outreach@lists.nasa.gov"
}
|
| description | Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells",
"format": "HTML",
"mediaType": "text/html",
"description": "GeneLab Study Page",
"downloadURL": "https://genelab-data.ndc.nasa.gov/genelab/accession/GLDS-91"
}
]
|
| identifier | nasa_genelab_GLDS-91_43bs-bf56 |
| issued | 2021-05-21 |
| keyword |
[
"data-processing",
"data-transformation",
"genelab-rnaseq-data-processing-protocol",
"growth-protocol",
"library-construction",
"microgravity-simulation",
"nucleic-acid-extraction",
"nucleic-acid-sequencing",
"treatment-protocol"
]
|
| landingPage | https://data.nasa.gov/dataset/a-study-of-gene-expression-influenced-by-simulated-microgravity-in-human-lymphoblastoid-ce |
| license | http://www.usa.gov/publicdomain/label/1.0/ |
| modified | 2025-04-23 |
| programCode |
[
"026:005"
]
|
| publisher |
{
"name": "National Aeronautics and Space Administration",
"@type": "org:Organization"
}
|
| theme |
[
"Earth Science"
]
|
| title | A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells |
