Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis
Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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"fn": "NIH",
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|
| description | Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion. |
| distribution |
[
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"@type": "dcat:Distribution",
"title": "Official Government Data Source",
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|
| identifier | https://healthdata.gov/api/views/ft2c-usuu |
| issued | 2025-07-13 |
| keyword |
[
"mmp-2-expression",
"nih",
"rheumatoid-arthritis",
"synovial-tissue",
"synovitis-erosions"
]
|
| landingPage | https://healthdata.gov/d/ft2c-usuu |
| modified | 2025-09-06 |
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"009:033"
]
|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis |
