Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue
Acute-phase serum amyloid A (A-SAA) is a major component of the
acute-phase response. A sustained acute-phase response in rheumatoid arthritis
(RA) is associated with increased joint damage. A-SAA mRNA expression was
confirmed in all samples obtained from patients with RA, but not in normal
synovium. A-SAA mRNA expression was also demonstrated in cultured RA
synoviocytes. A-SAA protein was identified in the supernatants of primary
synoviocyte cultures, and its expression colocalized with sites of macrophage
accumulation and with some vascular endothelial cells. It is concluded that
A-SAA is produced by inflamed RA synovial tissue. The known
association between the acute-phase response and progressive joint damage may
be the direct result of synovial A-SAA-induced effects on cartilage
degradation.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
]
|
| contactPoint |
{
"fn": "NIH",
"@type": "vcard:Contact",
"hasEmail": "mailto:info@nih.gov"
}
|
| description | Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
"description": "Visit the original government dataset for complete information, documentation, and data access.",
"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17807/"
}
]
|
| identifier | https://healthdata.gov/api/views/hrbk-n84y |
| issued | 2025-07-13 |
| keyword |
[
"acute-phase-response",
"nih",
"rheumatoid-arthritis",
"serum-amyloid-a",
"synovial-tissue"
]
|
| landingPage | https://healthdata.gov/d/hrbk-n84y |
| modified | 2025-09-06 |
| programCode |
[
"009:033"
]
|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue |
