Agonizing Hedgehog
It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work).
Complete Metadata
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| description | It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work). |
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| identifier | https://healthdata.gov/api/views/7jhn-i4gt |
| issued | 2025-07-14 |
| keyword |
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"agonist-identification",
"chemical-genetics",
"degenerative-diseases",
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| modified | 2025-09-29 |
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| theme |
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| title | Agonizing Hedgehog |
