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(Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
To determine the best way to select predictive groups of genes, we used published microarray data from dose-response studies on six chemicals in rats exposed orally for 5, 14, 28, and 90 days. We evaluated eight approaches for selecting genes for POD derivation and three previously proposed approaches (the lowest pathway BMD, and the mean and median BMD of all genes). This dataset is not publicly accessible because: The research which produced this data was not funded by EPA. The EPA coauthor helped write the manuscript. It can be accessed through the following means: Data generated by other authors. Format: N/A.
This dataset is associated with the following publication:
Farmahin, R., A. Williams, B. Kuo, N.L. Chepelev, R.S. Thomas, T.S. Burton-Maclaren, I.H. Curran, A. Nong, M.G. Wade, and C.L. Yauk. (Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment. Archives of Toxicology. Springer, New York, NY, USA, 91(5): 2045-2065, (2017).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Alexander Hanf",
"hasEmail": "mailto:hanf.alexander@epa.gov"
}
|
| description | To determine the best way to select predictive groups of genes, we used published microarray data from dose-response studies on six chemicals in rats exposed orally for 5, 14, 28, and 90 days. We evaluated eight approaches for selecting genes for POD derivation and three previously proposed approaches (the lowest pathway BMD, and the mean and median BMD of all genes). This dataset is not publicly accessible because: The research which produced this data was not funded by EPA. The EPA coauthor helped write the manuscript. It can be accessed through the following means: Data generated by other authors. Format: N/A. This dataset is associated with the following publication: Farmahin, R., A. Williams, B. Kuo, N.L. Chepelev, R.S. Thomas, T.S. Burton-Maclaren, I.H. Curran, A. Nong, M.G. Wade, and C.L. Yauk. (Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment. Archives of Toxicology. Springer, New York, NY, USA, 91(5): 2045-2065, (2017). |
| distribution |
[]
|
| identifier | https://doi.org/10.23719/1505450 |
| keyword |
[
"ExpoCast",
"exposure"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2016-12-07 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1007/s00204-016-1886-5"
]
|
| rights |
null
|
| title | (Archives of Toxicology) Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment |
