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Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization
The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1.
This dataset is associated with the following publication:
Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "John Wambaugh",
"hasEmail": "mailto:wambaugh.john@epa.gov"
}
|
| description | The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1. This dataset is associated with the following publication: Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019). |
| distribution |
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|
| identifier | https://doi.org/10.23719/1504435 |
| keyword |
[
"ExpoCast",
"exposure"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-05-08 |
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| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
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"subOrganizationOf": {
"name": "U.S. Government"
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|
| references |
[
"https://doi.org/10.1093/toxsci/kfz205"
]
|
| rights |
null
|
| title | Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization |
