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Compact, High-flow, Water-based, Turbulent-mixing, Condensation Aerosol Concentrator for Collection of Spot Samples

Published by Centers for Disease Control and Prevention | U.S. Department of Health & Human Services | Metadata Last Checked: January 23, 2026 | Last Modified: 2026-01-14
A new high-flow, compact aerosol concentrator, using rapid, turbulent mixing to grow aerosol particles into droplets for dry spot sample collection, has been designed and tested. The “TCAC (Turbulent-mixing, Condensation Aerosol Concentrator)” is composed of a saturator for generating hot vapor, a mixing section where the hot vapor mixes with the cold aerosol flow, a growth tube where condensational droplet growth primarily occurs, and a converging nozzle that focuses the droplets into a beam. The prototype concentrator utilizes an aerosol sample flow rate of 4 L min-1. The TCAC was optimized by varying the operating conditions, such as relative humidity of the aerosol flow, mixing flow ratio, vapor temperature, and impaction characteristics. The results showed that particles with a diameter ≥ 25 nm can be grown to a droplet diameter > 1400 nm with near 100 % efficiency. Complete activation and growth were observed at relative humidity ≥ 25 % of the aerosol sample flow. A consistent spot sample with a diameter of D90 = 1.4 mm (the diameter of a circle containing 90 % of the deposited particles) was obtained regardless of the aerosol particle diameter (dp = 20 – 1900 nm). For fiber counting applications using phase contrast microscopy, the TCAC can reduce the sampling time, or counting uncertainty, by two to three orders of magnitude, compared to the 25-mm-filter collection. The study shows that the proposed mixing-flow scheme enables a compact spot sample collector suitable for handheld or portable applications, while still allowing for high flow rates.

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