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Computational discovery of sense-antisense transcription in the human and mouse genomes

Published by National Institutes of Health | U.S. Department of Health & Human Services | Metadata Last Checked: September 07, 2025 | Last Modified: 2025-09-06
Overlapping but oppositely oriented transcripts have the potential to form sense-antisense perfect double-stranded (ds) RNA duplexes. A bioinformatics approach has identified over 217 candidate overlapping transcriptional units, bringing the total number of predicted and validated examples of overlapping but oppositely oriented transcripts to over 300.

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