Computational Estimates of Aggregate Exposure to PFOA/PFOS from 2011-2017 Using a Basic Intake and Pharmacokinetic Model
General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and published contact rates. These values were entered into a first-order PK model to estimate PFOS and PFOA blood serum concentrations. which were then compared measured concentrations reported by the 2013-2014 National Health and Nutrition Examination Survey (NHANES) measured concentrations. These methods are an expansion of the process taken by two previous studies, which predicted body burden from aggregate route intakes for PFOA and for PFOS, respectively.
This dataset is associated with the following publication:
East, A., P. Egeghy, E. Hubal, R. Slover, and D. Vallero. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 33: 56-68, (2023).
Complete Metadata
| accessLevel | public |
|---|---|
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| contactPoint |
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"fn": "Daniel Vallero",
"hasEmail": "mailto:vallero.daniel@epa.gov"
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| describedBy | https://pasteur.epa.gov/uploads/10.23719/1520464/documents/Table%201%20PFOA%20PFOS%20AE%20DAV%20.pdf |
| describedByType | application/pdf |
| description | General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and published contact rates. These values were entered into a first-order PK model to estimate PFOS and PFOA blood serum concentrations. which were then compared measured concentrations reported by the 2013-2014 National Health and Nutrition Examination Survey (NHANES) measured concentrations. These methods are an expansion of the process taken by two previous studies, which predicted body burden from aggregate route intakes for PFOA and for PFOS, respectively. This dataset is associated with the following publication: East, A., P. Egeghy, E. Hubal, R. Slover, and D. Vallero. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 33: 56-68, (2023). |
| distribution |
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"title": "Input 10052020 pfos_pfoa dav.xlsx",
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| identifier | https://doi.org/10.23719/1520464 |
| keyword |
[
"Data curation",
"aggregate exposure estimation",
"per and polyfluoroalkyl substances (PFAS)",
"perfluoroctanoic acid (PFOA)",
"perfluorooctane sulfonate (PFOS)",
"pharmacokinetic (PK) model"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2020-10-16 |
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| publisher |
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"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
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| references |
[
"https://doi.org/10.1038/s41370-021-00374-w"
]
|
| rights |
null
|
| title | Computational Estimates of Aggregate Exposure to PFOA/PFOS from 2011-2017 Using a Basic Intake and Pharmacokinetic Model |
