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Data File for iAs Dose-response Manuscripts - Data files used in preparing four manuscripts describing dose-response methods that have been developed for the purposes of the EPA inorganic arsenic IRIS health assessment.

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2018-07-26
These datasets contain information used in support of tables, figures and conclusions made in four manuscripts related to EPA methods developed for the dose-response analysis of epidemiological studies of arsenic health effects. This dataset is associated with the following publications: Hobbie, K., K. Shao, C. Henning, W. Mendez, Jr, J. Lee, I. Cote, I. Druwe, A. Davis, and J. Gift. Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 144: 1-14, (2020). Mendez, W., K. Shao, J. Lee, I. Cote, I. Druwe, A. Davis, and J. Gift. Model Averaging Methods for the Evaluation of Dose-Response Model Uncertainty When Assessing the Suitability of Studies for Estimating Risk. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 143: 1-11, (2020). Allen, B., K. Shao, K. Hobie, W. Mendez Jr, J. Lee, I. Cote, I. Druwe, J. Gift, and A. Davis. Systematic dose-response of environmental epidemiologic studies: Dose and Response Pre-Analysis. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 142: 105810, (2020). Allen, B., K. Shao, K. Hobbie, W. Mendez Jr, J. Lee, I. Cote, I. Druwe, J. Gift, and A. Davis. Bayesian Hierarchical Dose-response Meta-analysis of Epidemiological Studies : Modeling and Target Population Prediction Methods. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 145: 106111, (2020).

Resources

24 resources available

  • A_Summary_For_CaseControl_20161002_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • A_Summary_For_Cohort_20180713_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • Bladder and Lung Cancer Dose response Read Me_508.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
    Download

  • Data_Dictionary-MOE_paper_508.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
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  • Data_Dictionary_MR1_paper_508.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
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  • Data_Dictionary_MR2_paper_508.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
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  • S1-Bates1995_CE5_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S10-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.31_508.xlsx

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  • S11-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.6_508.xlsx

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  • S12-alternative_gamma_prior_results_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S2-Bates2004_DW4_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S3-Chen_2010_NE_Taiwan_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S4-Meliker2010_CE5_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S5-Gamma distribution for B_mean prior_508.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
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  • S5-Sawada_females_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S6 - bladder cancer lifetable results_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S6-Sawada_males_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S7-Steinmaus2003_CE5_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S8-Steinmaus2013_CE5_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S8-final bladder cancer Stan runs_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • S9-Wu2013_U&I_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • bootstrap_bladder_case_num_adj_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • bootstrap_lung_cases_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • bootstrap_mean_expo_march2016big_508.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
accessLevel public
bureauCode 
                                            [
  "020:00"
]
contactPoint 
                                            {
  "fn": "Jeffrey Gift",
  "hasEmail": "mailto:gift.jeff@epa.gov"
}
description These datasets contain information used in support of tables, figures and conclusions made in four manuscripts related to EPA methods developed for the dose-response analysis of epidemiological studies of arsenic health effects. This dataset is associated with the following publications: Hobbie, K., K. Shao, C. Henning, W. Mendez, Jr, J. Lee, I. Cote, I. Druwe, A. Davis, and J. Gift. Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 144: 1-14, (2020). Mendez, W., K. Shao, J. Lee, I. Cote, I. Druwe, A. Davis, and J. Gift. Model Averaging Methods for the Evaluation of Dose-Response Model Uncertainty When Assessing the Suitability of Studies for Estimating Risk. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 143: 1-11, (2020). Allen, B., K. Shao, K. Hobie, W. Mendez Jr, J. Lee, I. Cote, I. Druwe, J. Gift, and A. Davis. Systematic dose-response of environmental epidemiologic studies: Dose and Response Pre-Analysis. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 142: 105810, (2020). Allen, B., K. Shao, K. Hobbie, W. Mendez Jr, J. Lee, I. Cote, I. Druwe, J. Gift, and A. Davis. Bayesian Hierarchical Dose-response Meta-analysis of Epidemiological Studies : Modeling and Target Population Prediction Methods. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 145: 106111, (2020).
distribution 
                                            [
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    "title": "A_Summary_For_CaseControl_20161002_508.xlsx",
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    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/A_Summary_For_CaseControl_20161002_508.xlsx"
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    "title": "A_Summary_For_Cohort_20180713_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/A_Summary_For_Cohort_20180713_508.xlsx"
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  {
    "title": "Bladder and Lung Cancer Dose response Read Me_508.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/Bladder%20and%20Lung%20Cancer%20Dose%20response%20Read%20Me_508.docx"
  },
  {
    "title": "Data_Dictionary-MOE_paper_508.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/Data_Dictionary-MOE_paper_508.docx"
  },
  {
    "title": "Data_Dictionary_MR1_paper_508.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/Data_Dictionary_MR1_paper_508.docx"
  },
  {
    "title": "Data_Dictionary_MR2_paper_508.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/Data_Dictionary_MR2_paper_508.docx"
  },
  {
    "title": "S1-Bates1995_CE5_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S1-Bates1995_CE5_508.xlsx"
  },
  {
    "title": "S10-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.31_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S10-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.31_508.xlsx"
  },
  {
    "title": "S11-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.6_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S11-BC_Morbidity_Lifetable_10ugL_MLE_inh_bkg_0.6_508.xlsx"
  },
  {
    "title": "S12-alternative_gamma_prior_results_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S12-alternative_gamma_prior_results_508.xlsx"
  },
  {
    "title": "S2-Bates2004_DW4_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S2-Bates2004_DW4_508.xlsx"
  },
  {
    "title": "S3-Chen_2010_NE_Taiwan_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S3-Chen_2010_NE_Taiwan_508.xlsx"
  },
  {
    "title": "S4-Meliker2010_CE5_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S4-Meliker2010_CE5_508.xlsx"
  },
  {
    "title": "S5-Gamma distribution for B_mean prior_508.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S5-Gamma%20distribution%20for%20B_mean%20prior_508.docx"
  },
  {
    "title": "S5-Sawada_females_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S5-Sawada_females_508.xlsx"
  },
  {
    "title": "S6 - bladder cancer lifetable results_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S6%20-%20bladder%20cancer%20lifetable%20results_508.xlsx"
  },
  {
    "title": "S6-Sawada_males_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S6-Sawada_males_508.xlsx"
  },
  {
    "title": "S7-Steinmaus2003_CE5_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S7-Steinmaus2003_CE5_508.xlsx"
  },
  {
    "title": "S8-Steinmaus2013_CE5_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S8-Steinmaus2013_CE5_508.xlsx"
  },
  {
    "title": "S8-final bladder cancer Stan runs_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S8-final%20bladder%20cancer%20Stan%20runs_508.xlsx"
  },
  {
    "title": "S9-Wu2013_U&I_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/S9-Wu2013_U%26I_508.xlsx"
  },
  {
    "title": "bootstrap_bladder_case_num_adj_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/bootstrap_bladder_case_num_adj_508.xlsx"
  },
  {
    "title": "bootstrap_lung_cases_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/bootstrap_lung_cases_508.xlsx"
  },
  {
    "title": "bootstrap_mean_expo_march2016big_508.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502484/bootstrap_mean_expo_march2016big_508.xlsx"
  }
]
identifier https://doi.org/10.23719/1502484
keyword 
                                            [
  "dose-response",
  "inorganic arsenic"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2018-07-26
programCode 
                                            [
  "020:062"
]
publisher 
                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
                                            [
  "https://doi.org/10.1016/j.envint.2020.105810",
  "https://doi.org/10.1016/j.envint.2020.105857",
  "https://doi.org/10.1016/j.envint.2020.105986",
  "https://doi.org/10.1016/j.envint.2020.106111"
]
rights 
                                            null
title Data File for iAs Dose-response Manuscripts - Data files used in preparing four manuscripts describing dose-response methods that have been developed for the purposes of the EPA inorganic arsenic IRIS health assessment.

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