Data from: Lacticaseibacillus rhamnosus Strain GG (LGG) Regulate Gut Microbial Metabolites, an In Vitro Study Using Three Mature Human Gut Microbial Cultures in a Simulator of Human Intestinal Microbial Ecosystem (SHIME)
Using the SHIME (an in vitro simulator of the human gut microbiome) we studied changes in the gut metabolome that occurred in response to the administration of the Laticaseibacillus rhamnosus strain GG (LGG). Using fecal inoculum from three healthy human donors, reactors were established representing three colonic regions and both the luminal and mucosal microbiome in those regions. Samples were collected before, during, and after inoculation of the reactors with LGG.
This dataset includes untargeted metabolomics data. Shallow shotgun metagenomic sequencing data can be found in the NCBI Sequence Read Archive associated with BioProject PRJNA893635 : https://www.ncbi.nlm.nih.gov/bioproject/PRJNA893635.
Resources in this dataset:
Resource Title: Batch normalized metabolite peak area data
File Name: metabolites_individual_samples_batch_norm_non_imputed.csv
Resource Title: Sample metadata
File Name: LGG2_metadata.csv
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"005:18"
]
|
| contactPoint |
{
"fn": "Narrowe, Adrienne",
"hasEmail": "mailto:adrienne.narrowe@usda.gov"
}
|
| description | <p>Using the SHIME (an in vitro simulator of the human gut microbiome) we studied changes in the gut metabolome that occurred in response to the administration of the Laticaseibacillus rhamnosus strain GG (LGG). Using fecal inoculum from three healthy human donors, reactors were established representing three colonic regions and both the luminal and mucosal microbiome in those regions. Samples were collected before, during, and after inoculation of the reactors with LGG. </p> <p>This dataset includes untargeted metabolomics data. Shallow shotgun metagenomic sequencing data can be found in the NCBI Sequence Read Archive associated with BioProject PRJNA893635 : <a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA893635">https://www.ncbi.nlm.nih.gov/bioproject/PRJNA893635</a>. </p> <p>Resources in this dataset:</p> <ul> <li> <p>Resource Title: Batch normalized metabolite peak area data File Name: metabolites_individual_samples_batch_norm_non_imputed.csv</p> </li> <li> <p>Resource Title: Sample metadata File Name: LGG2_metadata.csv</p> </li> </ul> |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "LGG2_metadata.csv",
"format": "csv",
"mediaType": "application/csv",
"downloadURL": "https://ndownloader.figshare.com/files/44540696"
},
{
"@type": "dcat:Distribution",
"title": "metabolites_individual_samples_batch_norm_non_imputed_0.csv",
"format": "csv",
"mediaType": "text/plain",
"downloadURL": "https://ndownloader.figshare.com/files/44540699"
}
]
|
| identifier | 10.15482/USDA.ADC/1529131 |
| keyword |
[
"ARS",
"NP306",
"data.gov",
"metabolomics",
"probiotics"
]
|
| license | https://creativecommons.org/licenses/by/4.0/ |
| modified | 2025-11-21 |
| programCode |
[
"005:040"
]
|
| publisher |
{
"name": "Agricultural Research Service",
"@type": "org:Organization"
}
|
| spatial |
"{"type": "Point", "coordinates": [-75.187092456102, 40.078126249741]}"
|
| temporal | 2018-10-16/2019-04-07 |
| title | Data from: Lacticaseibacillus rhamnosus Strain GG (LGG) Regulate Gut Microbial Metabolites, an In Vitro Study Using Three Mature Human Gut Microbial Cultures in a Simulator of Human Intestinal Microbial Ecosystem (SHIME) |
