Dataset for Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health.
These data represent underlying data generated for the study titled 'Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health'. Data include extracellular vesicle particle count and size distribution from nanoparticle tracking analysis; microRNA expression data from mRNA sequencing in extracellular vesicles; PFAS signature data from mass spectrometry analysis of isolated HepG2 cell lysates and their secreted extracellular vesicles; in vitro cell viability data.
This dataset is associated with the following publication:
Carberry, C., J. Bangma, L. Koval, D. Keshava, h. Hartwell, M. Sokolsky, R. Fry, and J. Rager. Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved in liver health. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 197(2): 155-169, (2024).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Jacqueline Bangma",
"hasEmail": "mailto:bangma.jacqueline@epa.gov"
}
|
| description | These data represent underlying data generated for the study titled 'Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health'. Data include extracellular vesicle particle count and size distribution from nanoparticle tracking analysis; microRNA expression data from mRNA sequencing in extracellular vesicles; PFAS signature data from mass spectrometry analysis of isolated HepG2 cell lysates and their secreted extracellular vesicles; in vitro cell viability data. This dataset is associated with the following publication: Carberry, C., J. Bangma, L. Koval, D. Keshava, h. Hartwell, M. Sokolsky, R. Fry, and J. Rager. Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved in liver health. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 197(2): 155-169, (2024). |
| distribution |
[
{
"title": "PFASEVs_Tables.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529913/PFASEVs_Tables.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1529913 |
| keyword |
[
"Mixtures",
"PFAS",
"extracellular vesicles",
"liver toxicity"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html |
| modified | 2023-02-16 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfad108",
"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823775"
]
|
| rights |
null
|
| title | Dataset for Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health. |
